Biological medicines, also known as biological therapies or “biologics,” are medicines that are produced by living organisms, including human, animal, or microorganism cells. Today, they are commonly produced through biotechnology. Biologics can include proteins, sugars, and nucleic acids, as well as living entities such as gene therapies.
Infections, injection site reaction, headache & rash.
Biologics work by targeting particular chemicals or cells involved in the body’s immune system response. Anti-TNF drugs, for example, were the first biologics to be developed. These therapies work by blocking the activity of TNF, a chemical messenger. TNF itself has many different actions, so anti-TNF drugs result in many biological effects, which tend to reduce or stop different aspects of inflammation.
Vaccination should be given before starting treatment (e.g. influenza, polysaccharide Pneumovax, Hep B) and then during as appropriate when indicated. Live attenuated vaccines (e.g. BCG, yellow fever, herpes zoster and oral polio) are not recommended
These maybe repeated if appropriate (e.g. ANA, dsDNA if development of clinical SLE symptoms). The frequency and type of tests will also be influenced by usual monitoring requirements for other DMARDs if being used in combination with the TNFi.
Yes during pregnancy up to 1st Trimester if required and lactating mother also.
Adalimumab, given by subcutaneous injection with a special pre-filled syringe.
ADA should not be administered to the patients with hypersensitivity. Before you start taking biologics you should tell your doctor if you had any of following
Incidence rate of TB is < 0.1% in the patients treated more than 5 years with Ada
Minimum age is to start Ada is 2 year and there is no data suggesting maximum age limit for Ada therapy but be caution while treating elderly.
With other biologic DMARDS (e.g., Anakinra, abatacept) or other TNFi is not recommended.